Association between Body Condition and Oxidative Status in Dogs


Oxidative Stress (OS) is considered an underlying mechanism by which dysfunctional metabolism occurs in obese subjects but there are still very few studies in canine species. The purpose of this study was to evaluate simultaneously the effects of diet on body weight, oxidative and inflammatory status in a group of 12 adult dogs. The dogs were fed a maintenance diet, integrated with natural antioxidants, for a period of 6 months. At the beginning and the end of the trial, Body Condition Score (BCS) was evaluated and haematological (CBCs, Complete Blood Counts), oxidative parameters (d-ROMs, derivatives of Reactive Oxygen Metabolites; BAP, Biological Antioxidant Potential; Retinol; α-tocopherol) and inflammatory parameters (Fibrinogen; CRP, C Reactive Protein) were performed. Significant differences (p < 0.05) emerged about BCS, hematocrit (HCT), number of platelets (PLT), d-ROMs, BAP and retinol while no differences were for α-tocopherol, fibrinogen and CRP between the two periods of different diet. In this study, dogs showed an oxidative imbalance documented by the increase in d-ROMs and the reduction of BAP and retinol. Inflammatory parameters don’t change in relation to body weight like an alteration of the oxidative status could precede the onset of inflammation. The role of oxidative stress and of integration with antioxidants should be taken into special consideration in the dietary treatment in overweight dogs.

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A. Pasquini, S. Roberti, V. Meucci, E. Luchetti, S. Canello, G. Guidetti and G. Biagi, "Association between Body Condition and Oxidative Status in Dogs," Food and Nutrition Sciences, Vol. 4 No. 8A, 2013, pp. 191-196. doi: 10.4236/fns.2013.48A023.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] T. Fukui, K. Yamauchi, M. Maruyama, T. Yasuda, M. Kohno and Y. Abe, “Significance of Measuring Oxidative Stress in Lifestyle-Related Diseases from the Viewpoint of Correlation between d-ROMs and BAP in Japanese Subjects,” Hypertension Research: Official Journal of the Japanese Society of Hypertension, Vol. 34, No. 9, 2011, pp. 1041-1045.
[2] B. Halliwell, “Antioxidants in Human Health and Disease,” Annual Review of Nutrition, Vol. 16, 1996, pp. 33-50. doi:10.1146/
[3] V. B. Djordjevic “Free Radicals in Cell Biology,” International Review of Cytology, Vol. 237, 2004, pp. 57-89. doi:10.1016/S0074-7696(04)37002-6
[4] K. Kotani and N. Taniguchia, “The Association between Reactive Oxygen Metabolites and Metabolic Syndrome in Asymptomatic Japanese Men,” Journal of Clinical Medicine Research, Vol. 3, No. 5, 2011, pp. 247-251.
[5] R. Goyal, M. Singhai and A. F. Faizy, “Glutathione Peroxidase Activity in Obese and Nonobese Diabetic Patients and Role of Hyperglycemia in Oxidative Stress,” Journal of Mild-Life Health, Vol. 2, No. 2, 2011, pp. 72-76.
[6] D. Venturini, A. N. SimaoN. A. Scripes, L. D. Bahls, P. A. Melo, F. M. Belinetti, M. A. Lozovoy and I. Dichi, “Evaluation of Oxidative Stress in Overweight Subjects with or without Metabolic Syndrome,” Obesity, Vol. 20, No. 12, 2012, pp. 2361-2366. doi:10.1038/oby.2012.130
[7] W. Wonisch, A. Falk, I. Sundl, B. M. Winklhofer-Roob and M. Lindschinger, “Oxidative Stress Increases Continuously with BMI and Age with Unfavourable Profiles in Males,” Aging Male, Vol. 15, No. 3, 2012, pp. 159-165. doi:10.3109/13685538.2012.669436
[8] P. Codoner-Franch, V. Valls-Bellés, A. Arilla-Codoner and E. Alonso-Iglesias, “Oxidant Mechanisms in Childhood Obesity: The Link between Inflammation and Oxidative Stress,” Translational Research: The Journal of Laboratory and Clinical Medicine, Vol. 158, No. 6, 2011, pp. 369-384. doi:10.1016/j.trsl.2011.08.004
[9] Y. B. Tripathi and V. Pandey, “Obesity and Endoplasmic Reticulum (ER) Stresses,” Frontiers Inimmunolology, Vol. 3, 2012, p. 240.
[10] A. E. Tanner, J. Martin and K. E. Saker, “Oxidative Stress and Inflammatory State Induced by Obesity in the Healthy Feline,” Journal of Animal Physiology and Animal Nutrition (Berl.), Vol. 91, No. 3-4, 2007, pp. 163-166. doi:10.1111/j.1439-0396.2007.00680_7.x
[11] R. W. Grant, B. M. Vester Boler, T. K. Ridge, T. K. Graves and K. S. Swanson, “Adipose Tissue Transcriptome Changes during Obesity Development in Female Dogs” Physiological Genomics, Vol. 43, No. 6, 2011, pp. 295-307. doi:10.1152/physiolgenomics.00190.2010
[12] D. J. Laflamme, “Companion Animals Symposium: Obesity in Dogs and Cats: What Is Wrong with Being Fat?” Journal of Animal Science, Vol. 90, No, 5, 2012, pp. 1653-1662. doi:10.2527/jas.2011-4571
[13] A. J. German, S. Holden, G. L. Moxham, K. L. Holmes, R. M. Hackett and J. M. Rawlings, “Simple, Reliable Tool for Owners to Assess the Body Condition of Their Dog or Cat,” The Journal of Nutrition, Vol. 136, pp. 2031S2033S.
[14] A. Pasquini, E. Luchetti, V. Marchetti, E. L. Iorio and G. Cardini, “Analytical Performances of d-ROMs Test and BAP Test in Canine Plasma. Definition of the Normal Range in Healthy Labrador Dogs,” Veterinary Research Communication, Vol. 32, 2008, pp. 137-143. doi:10.1007/s11259-007-9014-x
[15] A. Tvarijonaviciute, J. J. Ceron, S. L. Holden, D. J. Cuthbertson, V. Biourge, P. J. Morris and A. J. German, “Obesity-Related Metabolic Dysfunction in Dogs: A Comparison with Human Metabolic Syndrome BMC,” Veterinary Research, Vol. 8, 2012, p. 147.
[16] I. Bondia-Pons, L. Ryan and J. A. Martinez, “Oxidative Stress and Inflammation Interactions in Human Obesity,” Journal of Physiology and Biochemistry, Vol. 68, No. 4, 2012, pp. 701-711. doi:10.1007/s13105-012-0154-2
[17] A. De Lorenzo, V. Del Gobbo, M. G. Premrov, M. Bigioni, F. Galvano and L. Di Renzo, “Normal-Weight Obese Syndrome: Early Inflammation?” American Journal of Clinical Nutrition, Vol. 85, 2007, pp. 40-45.
[18] S. Massimino and M. Hayek, “Effect of Supplemental Dietary Vitamin E and Beta-Carotene on Immune and Oxidative Parameters in Young and Old Beagle Dogs,” XVI ESVCP Congress Proceedings, Amsterdam, September 2006, pp. 14-16.
[19] E. Patterson, R. Wall, G. F. Fitzgerald, R. P. Ross and C. Stanton, “Health Implications of High Dietary Omega-6 Polyunsaturated Fatty Acids,” Journal of Nutrition and Metabolism, Vol. 2012, p. 16.
[20] F. Respondek, K. S. Swanson, K. R. Belsito, B. M. Vester, A. Wagner, L. Istasse and M. Diez, “Short-Chain Fructooligosaccharides Influence Insulin Sensitivity and Gene Expression of Fat Tissue in Obese Dogs,” Journal of Nutrition, Vol. 138, 2008, pp. 1712-1718.
[21] K. L. Gross and S. C. Zicker, “L-Carnitine Increases Muscle Mass, Bone Mass, and Bone Density in Growing Large Breed Puppies,” Journal of Animal Science, Vol. 78, 2000, p. 176.
[22] B. Halliwell, “Food Derived Antioxidants,” In: E. Cadenas and L. Packer, Eds., Handbook of Antioxidants, 2nd Edition, CRC Press, New York, 2002, pp. 1-46.
[23] H. S. Chaudhari, U. Bhandari and G. Khanna, “Preventive Effect of Embelin from Embelia Ribes on Lipid Metabolism and Oxidative Stress in High-Fat Diet-Induced Obesity in Rats,” Planta Medica, Vol. 78, No. 7, 2012, pp. 651-657. doi:10.1055/s-0031-1298379
[24] G. Kaur and C. Meena, “Amelioration of Obesity, Glucose Intolerance, and Oxidative Stress in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats by Combination Consisting of ‘Curcumin with Piperine and Quercetin’,” ISRN Pharmacology, Vol. 2012, 2012, p. 7.

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