Mohammadzadeh, N., Mehri, S. and Hosseinzadeh, H. (2017) Berberis vulgaris and Its Constituent Berberine as Antidotes and Protective Agents against Natural or Chemical Toxicities. Iranian Journal of Basic Medical Sciences, 20, 538-551.

has been cited by the following article:

• TITLE: Pharmacist’s Evaluation of Natural Ingredients in Topical Products for Rheumatoid Arthritis

  AUTHORS: Hanna Tillman, Juliana Gassmann, Shelby Stensgard, Alex Nguyen, Nicholas Tieu, Markus Melbardis, Hayden Gharibyar

  KEYWORDS: Rheumatoid Arthritis, Natural Ingredient, Topical Treatment, Anti-Inflammatory, Alternative Treatment

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.13 No.8, August 22, 2022

  ABSTRACT: Inflammatory diseases such as rheumatoid arthritis (RA) can lead to chronic pain and joint deformity. First line treatment includes disease-modifying antirheumatic drugs (DMARDs) to slow disease progression, but RA patients are often left with debilitating symptoms. This article explores alternative topical and naturally based options to treat RA symptoms, with supporting evidence for their use. Considered options include Aloe vera, Perillyl Alcohol (POH), Aleurites moluccana, Calendula officinalis extract (quercetin), Achyranthes species, Guizhi Shaoyao Zhimu, Curcumin (turmeric), Wutou, Radix paeoniae extract (Paeoniflorin), Tripterygium wilfordii Hook F (TWHF), Capsaicin, Cannabinoids (CBD), and Berberine. Many of these products show promising data for supplemental treatment of RA through various mechanisms, with CBD and TWHF having the most robust evidence supporting their use.