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has been cited by the following article:

• TITLE: Synthesis and Cytotoxicity of Heterocyclic Compounds Derived from Cyclohexane-1,3-Dione

  AUTHORS: Mohamed A. Shaaban, Mona M. Kamel, Yara R. Milad

  KEYWORDS: Cyclohexane-1, 3-Dione, Thiophene, Thiazole, Pyridazine, Cytotoxicity

  JOURNAL NAME: Open Access Library Journal, Vol.1 No.9, December 1, 2014

  ABSTRACT: Cyclohexane-1,3-dione (1) was used as a template to develop new anticancer compounds. The ring modification of compound 1occurred through its reaction with either aromaticaldehydes or benzenediazonium chloride to produce the corresponding products. The latter compounds underwenttheterocyclization reactions through the reaction with elemental sulfur and some active methylene reagents to produce tetrahydrobenzo[b]thiophene derivatives. The reaction of compound 1 with elemental sulfur and phenylisothiocyanategave the tetrahydrobenzo[d]thiazole derivative. The cytotoxicity of the newly synthesized products against human cancer and normal cell lines was evaluated. Some compounds showed high cytotoxicity against cancer cell lines. The results showed that compounds 3b, 5c, 7b, 10b, 12, 14b, 16, 18b, 19b, 20b, 21 and 24 showed the highest cytotoxicity. Moreover, the toxicity of twelve active compounds were measured.