Solvent-Free Synthesis of Carboxylic Acids and Amide Analogs of CAPE (Caffeic Acid Phenethyl Ester) under Infrared Irradiation Conditions


A convenient and easy method is described for the formation of carboxamides from carboxylic acids and primary amines in solventless conditions using infrared (IR) light. Thus, under IR light, cinnamic acid derivatives and amines can produce yields ranging from 50% to 85% of the resulting amide.

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Martínez-Soriano, P. , Macías-Pérez, J. , Velázquez, A. , Camacho-Enriquez, B. , Pretelín-Castillo, G. , Ruiz-Sánchez, M. , Abrego-Reyes, V. , Villa-Treviño, S. and Angeles, E. (2015) Solvent-Free Synthesis of Carboxylic Acids and Amide Analogs of CAPE (Caffeic Acid Phenethyl Ester) under Infrared Irradiation Conditions. Green and Sustainable Chemistry, 5, 81-91. doi: 10.4236/gsc.2015.52011.

Conflicts of Interest

The authors declare no conflicts of interest.


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