Solvent Free One-Pot Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles Catalyzed by Secondary Amine Based Ionic Liquid and Defective Keggin Heteropoly Acid

DOI: 10.4236/gsc.2013.34A002   PDF   HTML     4,525 Downloads   7,398 Views   Citations


Secondary amine based ionic liquid and defective Keggin type heteropoly acid (HPA) are separately used for efficient one-pot four-component synthesis of 1,2,4,5-tetrasubstituted imidazoles assisted by microwave (MW). Eco-friendly solvent free procedure, short reaction time, high yield of products and reusability of catalysts are important features of the synthesis. A comparative study on the efficiency of the two catalysts is reported. This work further demonstrates the alternate use of urea, instead of often used ammonium acetate, as source of nitrogen.

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P. Jyoti Das, J. Das, M. Ghosh and S. Sultana, "Solvent Free One-Pot Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles Catalyzed by Secondary Amine Based Ionic Liquid and Defective Keggin Heteropoly Acid," Green and Sustainable Chemistry, Vol. 3 No. 4A, 2013, pp. 6-13. doi: 10.4236/gsc.2013.34A002.

Conflicts of Interest

The authors declare no conflicts of interest.


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