Synthesis and Cytotoxicity of Heterocyclic Compounds Derived from Cyclohexane-1,3-Dione


Cyclohexane-1,3-dione (1) was used as a template to develop new anticancer compounds. The ring modification of compound 1occurred through its reaction with either aromaticaldehydes or benzenediazonium chloride to produce the corresponding products. The latter compounds underwenttheterocyclization reactions through the reaction with elemental sulfur and some active methylene reagents to produce tetrahydrobenzo[b]thiophene derivatives. The reaction of compound 1 with elemental sulfur and phenylisothiocyanategave the tetrahydrobenzo[d]thiazole derivative. The cytotoxicity of the newly synthesized products against human cancer and normal cell lines was evaluated. Some compounds showed high cytotoxicity against cancer cell lines. The results showed that compounds 3b, 5c, 7b, 10b, 12, 14b, 16, 18b, 19b, 20b, 21 and 24 showed the highest cytotoxicity. Moreover, the toxicity of twelve active compounds were measured.

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Shaaban, M. , Kamel, M. and Milad, Y. (2014) Synthesis and Cytotoxicity of Heterocyclic Compounds Derived from Cyclohexane-1,3-Dione. Open Access Library Journal, 1, 1-16. doi: 10.4236/oalib.1101115.

Conflicts of Interest

The authors declare no conflicts of interest.


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