Dietary γ-Aminobutyric Acid Shortens the Life Span of Stroke-Prone Spontaneously Hypertensive Rats
Nakamichi Watanabe, Naomi Washio
DOI: 10.4236/fns.2011.24043   PDF    HTML   XML   4,224 Downloads   7,023 Views   Citations


Dietary γ-amino butyric acid (GABA) has been suggested to decrease systolic blood pressure. This study aimed to ex-amine the effects of dietary GABA on the life span of stroke-prone spontaneously hypertensive rats (SHRSPs). In this study, life span was determined for SHRSPs provided 1% NaCl solution or 0.01% GABA in 1% NaCl solution as drinking water. The life span of the GABA-fed group (76.3 ± 1.65 days) was significantly shorter than that of the control group (81.6 ± 0.88 days). The results of this study may not be applicable to humans. Future studies will be necessary to elucidate the mechanism underlying this phenomenon.

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N. Watanabe and N. Washio, "Dietary γ-Aminobutyric Acid Shortens the Life Span of Stroke-Prone Spontaneously Hypertensive Rats," Food and Nutrition Sciences, Vol. 2 No. 4, 2011, pp. 301-303. doi: 10.4236/fns.2011.24043.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] S. Vemulapalli and M. Barletta, “The Role of the Sympathetic Nervous System in the Cardiovascular Effects of Systemically Administrated γ-Aminobutyric Acid,” Archives Internationales de Pharmacodynamie et de Thérapie, Vol. 267, No. 1, 1984, pp. 46-58.
[2] K. Ishikawa and S. Saito, “Effect of Intraventricular γ-Aminobutyric Acid (GABA) on Discrimination Learning in Rats,” Psychopharmacology, Vol. 56, No. 2, 1978, pp. 127-132. doi:10.1007/BF00431837
[3] H. Nakamura, T. Takishima, T. Kometani and H. Yokogoshi, “Psychological Stress-Reducing Effect of Chocolate Enriched with γ-Aminobutyric Acid (GABA) in Humans: Assessment of Stress Using Heart Rate Variability and Salivary Chromogranin A,” International Journal of Food Sciences and Nutrition, Vol. 22, Supplement 5, 2009, pp. 1-8.
[4] H. Kazuhiro, K. Masayuki and K. Kazuo, “Mechanism Underlying γ-Aminobutyric Acid-Induced Antihypertensive Effect in Spontaneously Hypertensive Rats,” European Journal of Pharmacology, Vol. 438, No. 1-2, 2002, pp. 107-113.
[5] K. Hayakawa, M. Kimura, K. Kasaha, K. Matsumoto, H. Sansawa and Y. Yamori, “Effects of a γ-Aminobutyric Acid-Enriched Dairy Product on the Blood Pressure of Spontaneously Hypertensive and Normotensive Wistar- -Kyoto Rats,” British Journal of Nutrition, Vol. 92, No. 3, 2004, pp. 411-417. doi:10.1079/BJN20041221
[6] H. Al Sarraf and L. Philip, “Increased Brain Uptake and CSF Clearance of 14C-Glutamate in Spontaneously Hy- pertensive Rats,” Brain Research, Vol. 24, No. 2, 2003, pp. 181-187. doi:10.1016/j.brainres.2003.09.034
[7] M. Al Awadi, A. Pavlik and H. Al Sarraf, “Increased Brain Uptake and Brain Efflux Transport of 14C-GABA in Spontaneously Hypertensive Rats,” Life Sciences, Vol. 79, No. 9, 2006, pp. 847-853. doi:10.1016/j.lfs.2006.02.039
[8] V. Carelli, F. Liberatore, L. Scipione, G. Giorgioni, A. D. Stefano and M. Impicciatore, “Synthesis and Biological Evaluation of GABA Derivatives Able to Cross the Blo- od-Brain Barrier in Rats,” Bioorganic & Medicinal Chemistry Letters, Vol. 13, No. 21, 2003, pp. 3765-3769. doi:10.1016/j.bmcl.2003.07.004
[9] K. A. Scoggan, H. Gruber and K. Lariviere, “A Missense Mutation in the Abcg5 Gene Causes Phytosterolemia in SHR, Stroke-Prone SHR, and WKY Rats,” Journal of Lipid Research, Vol. 44, No. 5, 2003, pp. 911-916. doi:10.1194/jlr.M200438-JLR200

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