V. Carelli, F. Liberatore, L. Scipione, G. Giorgioni, A. D. Stefano and M. Impicciatore, “Synthesis and Biological Evaluation of GABA Derivatives Able to Cross the Blo- od-Brain Barrier in Rats,” Bioorganic & Medicinal Chemistry Letters, Vol. 13, No. 21, 2003, pp. 3765-3769. doi:10.1016/j.bmcl.2003.07.004

has been cited by the following article:

• TITLE: Dietary γ-Aminobutyric Acid Shortens the Life Span of Stroke-Prone Spontaneously Hypertensive Rats

  AUTHORS: Nakamichi Watanabe, Naomi Washio

  KEYWORDS: γ-Amino Butyric Acid, Stroke-Prone Spontaneously Hypertensive Rat, Life Span

  JOURNAL NAME: Food and Nutrition Sciences, Vol.2 No.4, July 1, 2011

  ABSTRACT: Dietary γ-amino butyric acid (GABA) has been suggested to decrease systolic blood pressure. This study aimed to ex-amine the effects of dietary GABA on the life span of stroke-prone spontaneously hypertensive rats (SHRSPs). In this study, life span was determined for SHRSPs provided 1% NaCl solution or 0.01% GABA in 1% NaCl solution as drinking water. The life span of the GABA-fed group (76.3 ± 1.65 days) was significantly shorter than that of the control group (81.6 ± 0.88 days). The results of this study may not be applicable to humans. Future studies will be necessary to elucidate the mechanism underlying this phenomenon.