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has been cited by the following article:

• TITLE: Antinociceptive Effects of Pomegranate (Punica granatum L.) Juice and Seed Extracts on Acute Corneal Pain in Mice

  AUTHORS: Zahra Malek, Shirin Mansoori Dara, Mahsa Hadipour Jahromy

  KEYWORDS: Punica granatum, Morphine, Naloxone, Acute Corneal Pain, Mice

  JOURNAL NAME: World Journal of Neuroscience, Vol.4 No.2, April 18, 2014

  ABSTRACT: In the present study, the antinociceptive effects of acute (2, 4 and 6 ml/kg) and chronic (1, 2 and 3 ml/kg for 14 days)oral administration ofpomegranate (Punica granatumL.) juice and seedextract with or without morphine and naloxane were investigatedonhypertonic saline-induced acute corneal pain perception in mice. The number of eye wipes with a forelimb was counted for a period of 30 seconds as the criterion for pain assessment. Acute oral administration of the extract(at 6 ml/kg dose, once) and chronic oral administration(at 2 and 3 ml/kg for 14 days each) significantly decreased the number of eye wipes after subcutaneous injection of morphine (2 mg/kg, sc), naloxone (2 mg/kg, sc) and normal saline (2 mg/kg, sc) compared with control (p