TITLE:
Predicting residue contacts for protein-protein interactions by integration of multiple information
AUTHORS:
Tu Kien T. Le, Osamu Hirose, Vu Anh Tran, Thammakorn Saethang, Lan Anh T. Nguyen, Xuan Tho Dang, Duc Luu Ngo, Mamoru Kubo, Yoichi Yamada, Kenji Satou
KEYWORDS:
Residue-Residue Contacts;Domain-Domain Interactions; Protein-Protein Interactions; Domain Interfaces; Residue Co-Evolution; Contact Potentials
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.7 No.1,
January
24,
2014
ABSTRACT: Detailed
knowledge of interfacial region between interacting proteins is not only
helpful in annotating function for proteins, but also very important for
structure-based drug design and disease treatment. However, this is one of the
most difficult tasks and current methods are constrained by some factors. In
this study, we developed a new method to predict residue-residue contacts of
two interacting protein domains by integrating information about evolutionary
couplings andamino acid pairwise contact potentials, as well as domain-domain
interaction interfaces. The experimental results showed that our proposed
method outperformed the previous method with the same datasets. Moreover, the
method promises an improvement in the source of template-based protein docking.