Metabolic Syndrome and DNA Damage: The Interplay of Environmental and Lifestyle Factors in the Development of Metabolic Dysfunction
Giuseppe Potrick Stefani1,2*, Giovana Baldissera3, Ramiro Barcos Nunes1, Thiago Gomes Heck4,5, Cláudia Ramos Rhoden2,6
1Laboratory of Physiology, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
2Laboratory of Oxidative Stress and Atmospheric Pollution, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
3Laboratory of Toxicological Genetics, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
4Research Group in Physiology, Regional University of Northwestern State’s Rio Grande do Sul (UNIJUI), Ijuí, Brazil.
5Postgraduate Program in Integral Attention to Health, Regional University of Northwestern State’s Rio Grande do Sul (UNIJUI), Ijuí, Brazil.
6Department of Pharmacologic Sciences, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
DOI: 10.4236/ojemd.2015.57009   PDF   HTML   XML   4,160 Downloads   5,565 Views   Citations


The Metabolic Syndrome (MetS) is a complex condition which is characterized by increased risk factor for cardiovascular diseases, such as dyslipidemia, hypertension and central obesity, in addition to increased risk for type 2 diabetes mellitus (T2DM). All of these factors alone have a notable relationship with DNA damage. However, when the risks are combined, the extent for major outcomes being related to DNA damage (cancer), the consequence can be accelerated by the metabolic dysfunction. This article will illustrate the scientific evidence of the role of DNA damage in MetS, as well as discuss the interplay of major risks factors (air pollution, physical inactivity and dietary interventions) in genomic stability.

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Stefani, G. , Baldissera, G. , Nunes, R. , Heck, T. and Rhoden, C. (2015) Metabolic Syndrome and DNA Damage: The Interplay of Environmental and Lifestyle Factors in the Development of Metabolic Dysfunction. Open Journal of Endocrine and Metabolic Diseases, 5, 65-76. doi: 10.4236/ojemd.2015.57009.

Conflicts of Interest

The authors declare no conflicts of interest.


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