TITLE:
Metabolic Syndrome and DNA Damage: The Interplay of Environmental and Lifestyle Factors in the Development of Metabolic Dysfunction
AUTHORS:
Giuseppe Potrick Stefani, Giovana Baldissera, Ramiro Barcos Nunes, Thiago Gomes Heck, Cláudia Ramos Rhoden
KEYWORDS:
Metabolic Syndrome, DNA Damage, Diet, Physical Activity, Air Pollution
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.5 No.7,
July
27,
2015
ABSTRACT: The Metabolic Syndrome
(MetS) is a complex condition which is characterized by increased risk factor
for cardiovascular diseases, such as dyslipidemia, hypertension and central
obesity, in addition to increased risk for type 2 diabetes mellitus (T2DM). All
of these factors alone have a notable relationship with DNA damage. However,
when the risks are combined, the extent for major outcomes being related to DNA
damage (cancer), the consequence can be accelerated by the metabolic
dysfunction. This article will illustrate the scientific evidence of the role
of DNA damage in MetS, as well as discuss the interplay of major risks factors
(air pollution, physical inactivity and dietary interventions) in genomic
stability.