Potential Antidiabetic Activities of Probiotic Strains, L. acidophilus and L. bulgaricus against Fructose-Fed Hyperglycemic Rats - Food and Nutrition Sciences

FNS > Vol.10 No.12, December 2019

Volume 10, Issue 12 (December 2019)

ISSN Print: 2157-944X ISSN Online: 2157-9458

Google-based Impact Factor: 2.37 Citations

Potential Antidiabetic Activities of Probiotic Strains, L. acidophilus and L. bulgaricus against Fructose-Fed Hyperglycemic Rats ()

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DOI: 10.4236/fns.2019.1012101 1,122 Downloads 2,961 Views Citations

Author(s)

Md Shihab Uddin Sohag, Mollika Paul, Md Abdul Alim Al-Bari, Mir Imam Ibne Wahed, Md Rafiqul Islam Khan^*

Affiliation(s)

Department of Pharmacy, University of Rajshahi, Rajshahi, Bangladesh.

ABSTRACT

Background: Deregulation of the gut microbiota results in various pathological disorders such as diabetes, inflammation, cancer, dyslipidemia etc. Modulation of intestinal microbiota by probiotics may facilitate the management of a number of clinical conditions of diabetes. Methods: The present study was designed to investigate the effect of feeding low-fat probiotic yogurt containing L. acidophilus and L. bulgaricus on fructose-fed hyperglycemic rats. Yogurt containing L. acidophilus or L. bulgaricus (9.5 × 10⁹ cfu/rat/day) alone or in combination of both strains was supplied orally for 8 weeks concurrently with 20% fructose solution. Fasting blood glucose (FBG), oral glucose tolerance test, glycosylated hemoglobin (HbA1c), lipid profiles from blood and histopathological study of liver tissues were analyzed to evaluate anti-diabetic effect. Statistical analysis was done by Graph Pad Prism software. Values at p < 0.05 were considered statistically significant. Results: Administration of L. acidophilus or L. bulgaricus alone or in combination of both to hyperglycemic rats decreased serum FBG, onset of glucose intolerance, HbA1c, total cholesterol, triglycerides, LDL and VLDL-cholesterol, increased HDL-cholesterol levels significantly and preserved antioxidant pool such as activities of superoxide dismutase, catalase etc. Probiotic administration also prevented/repaired the oxidative damage of liver tissues. Conclusion: In conclusion, administration of yogurt containing L. acidophilus or L. bulgaricus that balanced the intestinal microbiota can prevent or lower risks of type-2 diabetes and its related complications.

KEYWORDS

Probiotics, Fructose-Fed Rats, Hyperglycemia, Dyslipidemia

Share and Cite:

Sohag, M. , Paul, M. , Al-Bari, M. , Wahed, M. and Khan, M. (2019) Potential Antidiabetic Activities of Probiotic Strains, L. acidophilus and L. bulgaricus against Fructose-Fed Hyperglycemic Rats. Food and Nutrition Sciences, 10, 1419-1432. doi: 10.4236/fns.2019.1012101.

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