Fasano, A., Berti, I., Gerarduzzi, T., Not, T., Colletti, R.B., Drago, S., Elitsur, Y., Green, P.H.R., Guandalini, S., Hill, I., Pietzak, M., Ventura, A., Thorpe, M., Kryszak, D., Fornaroli, F., Wasserman, S.S., Murray, J.A. and Horvath, K. (2003) A multicenter study on the sero-prevalence of celiac disease in the United States among both at risk and not at risk groups. Archives of Internal Medicine, 163, 286-292. doi:10.1001/archinte.163.3.286

has been cited by the following article:

• TITLE: A monocenter retrospective study of serological,histological and genetic characteristics of celiac disease in Northern Central Italy

  AUTHORS: Stefania Lombardi, Gloria Bertacca, Isabella Giannelli, Elena Bonomi, Daniela Tornaboni, Marco Culli, Andrea Cavazzana, Antonella Puccini, Paolo Franceschini, Marco Friggeri

  KEYWORDS: Celiac Disease; Anti-Endomysium Antibodies; Anti-Transglutaminase Antibodies; Epidemiology; HLA-DR

  JOURNAL NAME: Open Journal of Clinical Diagnostics, Vol.3 No.3, September 25, 2013

  ABSTRACT: Objective: To examine the seroprevalence, correlates and characteristics of Celiac disease (CD) in a population sample of a Northern Central Area of Italy, by a monocenter retrospective study. Methods: Between 2006 and 2010, serum samples of 9371 subjects (age range 6 months to 91 years) were screened for tissue transglutaminase IgA antibodies (IgA-tTG) by the Immunologia-Allergologia Unit of AUSL1 Massa-Carrara, an area with a population of approximately 150,000. Endomysial IgA antibodies (EMA), HLA typing and small-bowel biopsy were also performed when indicated. Results: Of the 9371 subjects, 269 (2.87%) had positive antibody tests. The population was divided into several age groups and the highest prevalence (5.63%) was found in the 6 months-3 years group. The prevalence of IgA-tTG positivity was double in females compared to males. All IgA-tTG positive patients that were genotyped carried HLA-DQ2 or DQ8, none was a5 positive only. In positive IgA-tTG sera, levels of IgA-tTG were significantly higher in EMA positive than in EMA negative sera (p in children and in adults. Ninety-five/269 IgA-tTG positive subjects underwent biopsy. IgA-tTG levels were different according to the histological degree of the lesion. When EMA were evaluated in IgA-tTG positive subjects the number of EMA negative sera was significantly higher in adults than in children. Conclusions: In summary, this study provides a monocenter retrospective analysis of serological, histological and genetic parameters of subjects with suspicion of CD in an area of Northern Central Italy from 2006 to 2010.