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has been cited by the following article:

• TITLE: Effect of Nicotine on Dopamine and Glutathione Levels in Presence of Oligoelements in Brain Regions of Young Rats——Effect of Nicotine on Brain Regions of Rat

  AUTHORS: David Calderón Guzmán, Ernestina Hernández García, Francisca Trujillo Jiménez, Gerardo Barragán Mejía, Hugo Juárez Olguín, José A. Saldivar González, Daniel Santamaria del Angel, Norma Osnaya Brizuela

  KEYWORDS: Glutathione; Lipid Peroxidation; Oxidative Stress

  JOURNAL NAME: Neuroscience and Medicine, Vol.3 No.3, September 25, 2012

  ABSTRACT: Aim: The purpose of this study was to understand the mechanism of nicotine mediated addiction and the role of oligoelements in reducing its effect. Methods: Male Wistar rats (weight 80 g) were treated with single and repeated doses of nicotine and/or oligoelements as follows: group 1 (control) NaCl 0.9%; group 2, nicotine (1 mg/kg); group 3, oligoelements (50 μl/rat); and group 4, nicotine (1 mg/kg) + oligoelements (50 μl/rat). All drugs were intraperitoneally administered for 4 days. Blood for the measurement of glucose was obtained from all the animals. Samples of the brain regions (cortex, hemispheres and cerebellum + medulla oblongata) of each rat were obtained and used to measure the concentrations of dopamine, GSH levels, and lipid peroxidation (TBARS) using fluorescence and spectrophotometric methods. Results: Glucose level increased in rats treated with nicotine and oligoelements (p