TITLE:
A New and Efficient Method for the Synthesis of Pyrimido[2,1-b]Benzothiazole Derivatives
AUTHORS:
Fatemeh Chadegani, Fatemeh Darviche, Saeed Balalaie
KEYWORDS:
4H-Pyrimido [2, 1-b] Benzothiazole; Tandem Knoevenagel-Michael Reaction; One-Pot Reaction; Green Chemistry
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.2 No.1,
March
15,
2012
ABSTRACT: The one-pot three-component reaction of 2-aminobenzothiazole, benzaldehyde derivatives and β-ketoester, β-diketone or malonate derivatives in solvent-free conditions provides the corresponding pyrimido [2,1-b] benzothiazole derivatives at 60?C in 60% - 72% yields without using any catalyst in an optimistic time.