TITLE:
Construction of a Cervical Cancer-Specific CeRNA Prognostic Regulatory Network
AUTHORS:
Dan Liu, Shanquan Yan, Yunhui Yang
KEYWORDS:
Biomarkers, Cervical Cancer, Competitive Endogenous RNA, Differentially Expressed RNA
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.13 No.8,
August
22,
2025
ABSTRACT: Objective: Cervical Cancer is the most common malignant tumor of the female genital tract. Previous studies have shown that ceRNA regulation plays an important role in cervical cancer. This study explored biomarkers related to the prognosis of cervical cancer by constructing a ceRNA network. Methods: Using bioinformatics, and the lncRNA was used for survival analysis, thus constructing a ceRNA network associated with cervical cancer. Results: MSRB3 expression was positively associated with B cell, CD4+ T cell, macrophage, and dendritic cell infiltration, and negatively associated with CD8+ T cell and neutrophil infiltration. MSRB3 expression also correlated with significantly higher expression of programmed death 1 (PD-1), programmed death ligand 1 (PD-L1), and cytotoxic T lymphocyte-associated protein4 (CTLA4). MSRB3 was found to be expressed in higher levels in cervical cancer tissues than in normal tissues and patients with high MSRB3 expression had a worse prognosis than those with low MSRB3 expression. Conclusion: The increase in the expression of MSRB3 related to CESC is significantly associated with the level of immune cell infiltration. The MSRB3 gene is a promising candidate for the treatment of endocervical adenocarcinoma and could serve as a potential biomarker for the treatment and diagnosis of endocervical carcinoma.