TITLE:
Guiera senegalensis Alleviates Ischemia Renal Reperfusion Injury in Albinos Wistar Rats
AUTHORS:
Mama Sy, Fatoumata Bah, Mouhamed Chérif Dial, Robert Foko, Racha Kamenda Ibondou, Cheikh Diop, Abdoulaye Séga Diallo
KEYWORDS:
Ischemia Reperfusion, Acute Kidney Injury, Guiera senegalensis, Tubular Degenerescence
JOURNAL NAME:
Open Journal of Pathology,
Vol.15 No.1,
January
26,
2025
ABSTRACT: Introduction: Renal ischemia-reperfusion (IR) is responsible for injuries such as destruction or dysfunction of tubular epithelial cells with inflammatory reaction and oxidative stress. Several therapeutic methods have been tested to alleviate ischemia-perfusion injury, ranging from using anti-inflammatory drugs, antioxidants, and plants from traditional pharmacopeia to administering RNA interference. However, there is currently no effective therapeutic option available for the treatment of renal IR injury, other than supportive therapies such as renal replacement therapy or hydration. Objective: This present study aimed to evaluate the effect of Guiera senegalensis on renal ischemia reperfusion, a recognized plant for its antioxidant and anti-inflammatory properties. Materials and Methods: Twenty-four (24) adult male Wistar rats were divided into four following groups: SLAM (subjected to a median laparotomy with simulated ischemia); GUIERRA (animals that received 250 mg/kg of guierra senegalensis orally, once a day, for 5 days, with simulated renal ischemia); IR (animals that underwent laparotomy followed by clamping of bilateral renal pedicles for 45 min and followed by reperfusion); GUIERRA + IR (animals given GUIERRA at the dosage of 250 mg/kg per day, for 5 days and then subjected to renal ischemia-reperfusion). Data analysis was performed by ANOVA, and a significance level of p Results: Compared with the I/R group, rats in the GUIERRA + IR group showed reduced histopathological damage scores (p Conclusion: The results of this preliminary work suggest that Guiera senegalensis decreases the degree of tissue damage in renal ischemia-reperfusion cases. This plant seems to be a promising therapeutic; further studies could help to precise the targets of its compounds on ischemia-reperfusion pathways.