TITLE:
Efficient Solvent-Free Preparation of Imines, and Their Subsequent Oxidation with m-CPBA to Afford Oxaziridines
AUTHORS:
Luis Álvarez-Santamaría, Eusebio Juaristi, Alexa Berenice Arroyo-Colín, Jorge Palma-Flores, Fanny Araceli Cabrera-Rivera, Jaime Escalante
KEYWORDS:
Solvent-Free Reaction, Imines, Oxaziridines, Oxidation Reaction, m-CPBA
JOURNAL NAME:
Green and Sustainable Chemistry,
Vol.9 No.4,
November
5,
2019
ABSTRACT: A simple one-pot procedure for the preparation of imines from the corresponding aldehydes and amines, and their subsequent oxidation reaction with m-CPBA to produce synthetically useful oxaziridines is reported. The method is applicable to imines derived from both aliphatic and aromatic aldehydes and diverse alkyl amines. Short reaction times, essentially quantitative yields, very mild reaction conditions, and easy purification are the main features of the procedure reported herein.