TITLE:
New Developments in the Mechanism of Drug Action and Toxicity of Conjugated Imines and Iminiums, including Related Alkaloids
AUTHORS:
Peter Kovacic, Ratnasamy Somanathan
KEYWORDS:
Mechanism of Drug, Alkaloids
JOURNAL NAME:
Open Journal of Preventive Medicine,
Vol.4 No.7,
July
29,
2014
ABSTRACT:
This review deals with
mechanism and physiological activity of conjugated imine and iminium species,
including those in the alkaloid category. An appreciable number can be found in
the Merck Index. There is focus in mode of action on electron transfer (ET),
reactive oxygen species (ROS), oxidative stress (OS) and reduction potential in
the prior review. These aspects can be involved in both therapeutic action
and toxicity. A unifying mechanistic approach involving ET-ROS-OS is applied to
synthetic drugs and alkaloids in the imineiminium category in relation to both
beneficial and adverse effects. Insight at the basic, molecular level can aid
in practical pharmaceutical design.