Article citationsMore>>
Lieb, W., Beiser, A.S., Vasan, R.S., Tan, Z.S., Au, R., Harris, T.B., Roubenoff, R., Auerbach, S., DeCarli, C., Wolf, P.A. and Seshadri, S. (2009) Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging. JAMA: The Journal of the American Medical Association, 302, 2565-2572.
doi:10.1001/jama.2009.1836
has been cited by the following article:
-
TITLE:
Leptin rescues neurons from Alzheimer’s disease-related pathways triggered by lipid burden
AUTHORS:
Steven J. Greco, George Perry, J. Wesson Ashford, Ashkan Hamzelou, Jane M. Johnston, Nikolaos Tezapsidis
KEYWORDS:
Leptin; Cholesterol; Ceramide; AMPK; SIRT; Alzheimer’s; Tau; Amyloid-β
JOURNAL NAME:
Advances in Alzheimer's Disease,
Vol.2 No.1,
March
12,
2013
ABSTRACT:
Adipocyte-derived leptin is a pleiotropic hormone implicated in control of lipid storage and mobilization, bone homeostasis, immune function and neuronal plasticity. Leptin has been shown to prevent accumulation of extracellular Aβ and hyperphosphorylation of tau in both cell culture and animal models. Herein an investigation was undertaken to test leptin’s ability to prevent the exacerbation/activation of AD-related pathways in neurons following their exposure to a high concentration of a variety of lipids. Specifically, cholesterol, oleic acid and/or ceramide were added to the media of cells resulting in decreased cellular viability and energy metabolism, and in increased tau phosphorylation and extracellular Aβ. Leptin increased viability, boosted cellular metabolism by activating AMP-activated protein kinase (AMPK) and the sirtuins (SIRT) and reduced tau phosphorylation and Aβ accumulation in a dose-dependent manner in response to select challenges. These findings demonstrate that leptin can attenuate the harmful effect of certain lipids that lead to exacerbation or activation of AD pathways. The study herein also provides the basis for a novel screening platform to define and identify a novel class of “metabolic” compounds addressing Alzheimer’s disease, based on a biological profile similar to leptin.
Related Articles:
-
Misha Patel
-
Lilia Mesrob, Marie Sarazin, Valerie Hahn-Barma, Leonardo Cruz de Souza, Bruno Dubois, Patrick Gallinari, Serge Kinkingnéhun
-
Iliass Charif, Mohamed El Abkari, Adil Ibrahimi, Mounia El Yousfi, Mounia El Yousfi
-
Afeez Abiola Hazzan, Harry Shannon, Jenny Ploeg, Parminder Raina, Mark Oremus
-
Toshio Hamagishi, Toshimitsu Inagawa, Yasuhiro Kambayashi, Hiromasa Tsujiguchi, Masami Kitaoka, Junko Mitoma, Hiroki Asakura, Fumihiko Suzuki, Daisuke Hori, Enoch Olando Anyenda, Nguyen Thi Thu Thao, Yuri Hibino, Koichi Hayashi, Aki Shibata, Takiko Sagara, Jiro Okochi, Kiyoshi Takamoku, Kotaro Hatta, Tadashi Konoshita, Hiroyuki Nakamura