The association of Crohn’s disease with celiac disease


We report two cases of a man and a woman whose association of Crohn’s disease (CRD) and celiac disease (CD) was evident and significant. The characteristic of our patients was the young age of discovery, and the localization of the CRD which was different in the two cases: colic localization in the woman and ileal stenosing in the man. The diagnosis of MCO was confirmed by the histological study of the jejunal biopsies in both cases and by serologies (anti-gliadines Antibody) in one case. Through these two observations, we insist on the singularity of the association of the celiac disease to the Crohn’s disease and on the complex etiopathogenesis of CRD which could have common points with that of CD. This fact can help us to understand more the two diseases and thereafter master their management.

Share and Cite:

Charif, I. , Abkari, M. , Ibrahimi, A. , Yousfi, M. and Yousfi, M. (2012) The association of Crohn’s disease with celiac disease. Open Journal of Gastroenterology, 2, 184-186. doi: 10.4236/ojgas.2012.24036.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Kitis, G., et al. (1980) Association of coeliac disease and inflammatory bowel disease. Gut, 21, 636-641. doi:10.1136/gut.21.7.636
[2] Karoui, S., et al. (2000) Association of asymptomatic celiac disease and Crohn’s disease. Annals of Internal Medicine (Paris), 151, 411-412.
[3] Gillberg, R., Dotevall, G. and Ahren, C. (1982) Chronic inflammatory bowel disease in patients with coeliac disease. Scandinavian Journal of Gastroenterology, 17, 491- 496. doi:10.3109/00365528209182237
[4] Chakraborty, A., et al. (2003) Coeliac disease and Crohn’s disease: An association not to be forgotten. Hospital Medicine, 64, 684-685.
[5] Leeds, J.S., et al. (2007) Is there an association between coeliac disease and inflammatory bowel diseases? A study of relative prevalence in comparison with population controls. Scandinavian Journal of Gastroenterology, 42, 1214-1220. doi:10.1080/00365520701365112
[6] Snook, J.A., de Silva, H.J. and Jewell, D.P. (1989) The association of autoimmune disorders with inflammatory bowel disease. The Quarterly Journal of Medicine, 72, 835-840.
[7] Cottone, M., et al. (1989) Familial association of Crohn’s and coeliac diseases. Lancet, 2, 338. doi:10.1016/S0140-6736(89)90527-8
[8] Ventura, A., Magazzu, G. and Greco, L. (1999) Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP study group for autoimmune disorders in celiac disease. Gastroenterology, 117, 297-303. doi:10.1053/gast.1999.0029900297
[9] Curtis, W.D., Schuman, B.M. and Griffin, J.W., Jr. (1992) Association of gluten-sensitive enteropathy and Crohn’s colitis. American Journal of Gastroenterology, 87, 1634-1637.
[10] Cheikh, I., et al. (2003) Association of celiac disease and Crohn’s disease. A case report. Revue de Médecine Interne, 24, 755-756. doi:10.1016/S0248-8663(03)00246-7

Copyright © 2023 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.