TITLE:
Primary CNS Marginal Zone Lymphoma: A Case Report and Review of the Literature
AUTHORS:
Barina Aqil, Emilie Rouah, Gordana Verstovsek
KEYWORDS:
Primary CNS Lymphoma; MZL
JOURNAL NAME:
Open Journal of Pathology,
Vol.3 No.2,
April
19,
2013
ABSTRACT:
Primary central
nervous system lymphoma (PCNSL) is a rare subtype of extranodal non-Hodgkin lymphoma
(NHL) located in the craniospinal axis (affecting CNS, meninges and eye) without
evidence of a systemic primary tumor. CNS lymphomas are typically high grade, large
cell lymphomas; low grade CNS lymphomas are rare. We encountered a case of 48-year
old patient with recurrent episodes of seizures, weakness of bilateral extremities
and memory loss. On MRI and CT scan, a 2.0
cm area of ill-defined enhancement with associated edema was present
in the left frontal subcortex. The biopsy revealed an infiltrate of small lymphocytes
expressing pan B-cell markers and an immunoprofile consistent with an extranodal
marginal zone B cell lymphomas of mucosa associated lymphoid tissue (MALT). Clonal
rearrangement was demonstrated by PCR analysis. Subsequently, the patient was treated
with radiation therapy and responded well, with decrease in the size of the lesion.
He is alive and well for 1 year and 3 months up to the date of this report.