TITLE:
Concomitant Occurrence of Segmental Neurofibromatosis and Lung Adenocarcinoma
AUTHORS:
Ryoko Morita, Naoki Oiso, Akira Kawada
KEYWORDS:
Segmental Neurofibromatosis; Lung Adenocarcinoma; Internal Malignant Tumors
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.2 No.4,
December
27,
2012
ABSTRACT: Neurofibromatosis type 1 (NF1) caused by a loss-of functional mutation in NF1 encoding neurofibromin is an autosomal dominant disorder characterized by café-au-lait spots, neurofibromas, intertriginous freckles, and Lisch nodules. Segmental neurofibromatosis (SN) represents a postzygotic mutation and loss of heterozygosity in neurofibromin. SN occurring in the elder persons may be associated with internal malignant tumors. Here, we reported a case of 58-year-old woman with concomitant occurrence of SN and lung adenocarcinoma. The onset of SN in aged persons would be a sign of concomitant occurrence of internal malignant tumors.