Concomitant Occurrence of Segmental Neurofibromatosis and Lung Adenocarcinoma


Neurofibromatosis type 1 (NF1) caused by a loss-of functional mutation in NF1 encoding neurofibromin is an autosomal dominant disorder characterized by café-au-lait spots, neurofibromas, intertriginous freckles, and Lisch nodules. Segmental neurofibromatosis (SN) represents a postzygotic mutation and loss of heterozygosity in neurofibromin. SN occurring in the elder persons may be associated with internal malignant tumors. Here, we reported a case of 58-year-old woman with concomitant occurrence of SN and lung adenocarcinoma. The onset of SN in aged persons would be a sign of concomitant occurrence of internal malignant tumors.

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R. Morita, N. Oiso and A. Kawada, "Concomitant Occurrence of Segmental Neurofibromatosis and Lung Adenocarcinoma," Journal of Cosmetics, Dermatological Sciences and Applications, Vol. 2 No. 4, 2012, pp. 265-266. doi: 10.4236/jcdsa.2012.24050.

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The authors declare no conflicts of interest.


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