TITLE:
Modulation of human B lymphocyte differentiation by therapeutic immunoglobulins: from protein to mRNA levels
AUTHORS:
Nathalie Dussault, Nellie Dumont, Sonia Néron
KEYWORDS:
Human B Lymphocytes; CD40-CD154; IVIg; Differentiation; Immunomodulation
JOURNAL NAME:
Open Journal of Immunology,
Vol.1 No.3,
December
31,
2011
ABSTRACT: Several groups are investigating the mechanisms of action of therapeutic immunoglobulins (IVIg) in order to improve their use. In vitro models such as CD40-CD154 interaction are necessary to study the physiological response of human B lymphocytes to IVIg. Human B lymphocytes treated with IVIg triggers a rapid phospho-rylation (