F. A. Abu-Shanab, A. D. Redhouse, J. R. Thompson and B. J. Wakefield, “Synthesis of 2,3,5,6-Tetrasubstituted Pyridines from Enamines Derived from N,N-Dimethyl- formamide Dimethyl Acetal,” Synthesis, Vol. 5, 1995, pp. 557-560. doi:10.1055/s-1995-3954

has been cited by the following article:

• TITLE: Dimethylformamide Dimethyl Acetal (DMFDMA) in Heterocyclic Synthesis: Synthesis of Polysubstituted Pyridines, Pyrimidines, Pyridazine and Their Fused Derivatives

  AUTHORS: Fathi A. Abu-Shanab, Sayed A. S. Mousa, E. A. Eshak, Ahmed Z. Sayed, Ahmed Al-Harrasi

  KEYWORDS: DMFDMA, Malononitrile Dimer, Pyridazine-3, 5-carbonitrile, Pyridine-4-alkoxide

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.1 No.4, December 27, 2011

  ABSTRACT: Reaction of N,N’-dimethylformamide dimethyl acetal (DMFDMA) with malononitrile dimer 8 (1:1) mole afforded 9 while, this reaction when carried out in (2:1) mole to give amidine 11 which can be used for the preparation of pyrimidine 13, amidine 14 and pyridine 19 when reacted with 4-nitroaniline, 4-methylaniline and alkoxide respectively. Malononitrile dimer reacted with diazonium chloride to give pyridazine 21, which can be reacted with DMFDMA, AcOH/HCl and cyanoacetamide to give pyridazine 22, 23 and pyrido[4,3-c] pyridazine 24 respectively. The latter reacted with DMFDMA to afford tricyclic compound 25.