TITLE:
Synthesis, Biological Evaluation, and SAR Studies of Varyingly Substituted 4-Thioflavonols
AUTHORS:
Rubina Bibi, Amina Sadiq, Ehsan Ullah Mughal
KEYWORDS:
Flavonols, 4-Thioflavonols, Flavonoids, Lawsons Reagent, Antibacterial Activity, Antifungal Activity, One Pot Synthesis, Sulfur Compounds, SAR Studies
JOURNAL NAME:
Open Journal of Medicinal Chemistry,
Vol.12 No.2,
June
30,
2022
ABSTRACT: A series of 4-thioflavonols compounds were synthesized by treating
flavonols with lawsons reagent with variable substituent groups at A, B, and AB
rings. All the synthesized compounds were
checked for antibacterial and antifungal activity. We report that many
compounds were found active against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, bacterial strains and, C. albicans, C. parapsilosisstrains and C. krusei fungal strains. Most of the synthesized 4-thioflavonols compounds were found to show enhanced antimicrobial activity than
respective flavonol compounds.