Popovici, C., Pavel, C.M., Sunel, V., Cheptea, C., Dimitriu, D.G., Dorohoi, D.O., David, D., et al. (2021) Optimized Synthesis of New Thiosemicarbazide Derivatives with Tuberculostatic Activity. International Journal of Molecular Sciences, 22, Article ID: 12139.
https://doi.org/10.3390/ijms222212139

has been cited by the following article:

• TITLE: Study of Biological Activity and Toxicity of Thiosemicarbazides Carbohydrate Derivatives by in Silico, in Vitro and in Vivo Methods

  AUTHORS: Baktygul Ernazarova, Taitokur Zhusubaliev, Zarylkan Asilbek kyzy, Aida Bakirova, Gulsara Zhusupbaeva, Orozby Akparalieva, Zhypargul Abdullaeva, Nasibakhon Razykova, Asilkan Dzhumanazarova, Galina Apryshko, Alina Orozmatova

  KEYWORDS: Biological Activity, Synthesis, Urea, Carbohydrate, Compounds, Hyperurcemia, Ototoxicity, Testing, Toxicity, Anti Tuberculosis, Antitumor

  JOURNAL NAME: Journal of Agricultural Chemistry and Environment, Vol.11 No.1, January 20, 2022

  ABSTRACT: Computer analysis of N-(β-D-galactopyranosyl)-thiosemicarbazide compounds by in silico method revealed high probability of antibacterial (antimycobacterial), anti-tuberculosis (antituberculosic), antiviral (Influenza), antitumor (antineoplastic) 9 > Pa > 0.5 and with a low probability of cytotoxic/cytostatic (cytostatic/cytotoxic) activities. An experimental study by in vitro and in vivo methods allowed us to conclude that studied new synthetic compound N-(β-D-galactopyranosyl)-thiosemicarbazide in the studied concentrations has a pronounced bactericidal and bacteriostatic effects.