Smith, E.M., Sorota, S., Kim, H.M., McKittrick, B.A., Nechuta, T.L., Bennett, C., Knutson, C., Burnett, D.A., Kieselgof, J., Tan, Z., Rindgen, D., Bridal, T., Zhou, X., Jia, Y.-P., Dong, Z., Mullins, D., Zhang, X., Priestley, T., Correll, C.C., Tulshian, D., Czarniecki, M. and Greenlee, W.J. (2010) T-Type Calcium Channel Blockers: Spiro-Piperidine Azetidines and Azetidinones-Optimization, Design and Synthesis. Bioorganic & Medicinal Chemistry Letters, 20, 4602-4606.
https://doi.org/10.1016/j.bmcl.2010.06.012

has been cited by the following article:

• TITLE: Environmentally Friendly Syntheses of Imines Applying the Pressure Reduction Technique: Reaction Cases of Less Reactive Amines and Studies by Computational Chemistry

  AUTHORS: Shoko Suzuki, Hiroyuki Ito, Motoyoshi Noike, Shinji Ishizuka, Risehiro Nonaka, Kenji Funaki, Takeshi Kodama, Shujiro Sakaki, Tomomichi Nishino, Mina Ito, Toranosuke Takahasi, Yasuo Yokoyama

  KEYWORDS: Solvent-Free, Catalyst-Free, Pressure Reduction Technique, Imine, Computational Chemistry

  JOURNAL NAME: Green and Sustainable Chemistry, Vol.10 No.1, January 21, 2020

  ABSTRACT: Recently, the development of environmentally friendly syntheses of imine derivatives, which were attracting great attention for their reactivity and structure in various fields, progressed rapidly because the concept of green chemistry had deeply penetrated into society. In our previous work, we had reported new synthetic methods of imine derivatives using some active amines under solvent- and catalyst-free reaction conditions. This synthetic reaction proceeded smoothly and target compounds were obtained in excellent yields. In this system, when less reactive amines were used as substrates, the synthetic reaction was not finished in the short reaction time, and the corresponding compounds were given in moderate yields. In order to solve this point, we tried to improve the reaction conditions of this method. Through this improvement, it was found that pure target compounds could be obtained in excellent yields by using 1.1 equivalents of less reactive amines to aldehydes and extending the reaction time compared with our previous work. In this paper, we will introduce the detail of this study, and also report the result of the investigation of the reaction property by computational chemistry.