J. L. Meyer and W. C. Thomas Jr., “Trace Metal-Citric Acid Complexe as Inhibitors of Calcification and Crystal Growth. I-Effects of Fe(III), Cr(III) and Al(III) Com-plexes on Calcium Phosphate Crystal Growth,” Journal of Urology, Vol. 128, No. 6, 1982, pp. 1376-1378.

has been cited by the following article:

• TITLE: Molecular Modeling of Chemicals Products Inhibitors of Growth Struvite Crystal

  AUTHORS: Mohamed Beghalia, Hocine Allali, Saïd. Ghalem, Aïssa. Belouatek, Abdelhamid Sari

  KEYWORDS: Inhibitors, Struvite, Modeling, Interactions, Docking, MM, DM

  JOURNAL NAME: Advances in Molecular Imaging, Vol.1 No.3, October 14, 2011

  ABSTRACT: Struvite (MgNH4PO46H2O) crystals were produced by infection associated with urea generating organ- isms.The aim of this study is to examine the interactions between the enzyme urease and two inhibitors, the first is an inhibitor monoatomic: Aluminum and the second is a polyatomic: Citrate by the methods of molecular modeling: molecular mechanics, molecular dynamics (MM+, AMBER) and molecular docking (FleX). Supersaturated solutions induce crystallization by nucleation and subsequent crystal growth .The mechanisms for the formation of calcium phosphate urinary stones are still not understood. Chemicals prod- uct has been studied extensively as inhibitors and has been observed in the attachment of crystals to in vitro study. As a complement we have using an electron microscope Hitachi TM1000, we examined specimens of crystals struvite. The various figures show a set of grains of sizes of the order of 20 µm. The majority of these particles present regular forms. This suggests the crystal growing. This result to an alteration in the expression of these faces and the development of a characteristic architectural struvite morphology. Similar changes were observed in the presence of identical concentrations of citrate acid, and Alluminuium, emphasizing the unique interaction of phosphocitrate with the struvite crystal.