The influence of chromium ions on the growth of the calcium hydroxyapatite crystal


Hydroxyapatite (Ca10(PO4)6(OH)2) is widely used as bio-ceramic materials and as adsorbents for separation of bio-molecules. These materials have also been used as adsorbents for heavy metals, supports and as catalysts in oxidation and dehydrogenation reactions. The catalytic performance of these materials depend on the lattice substitution of Ca sites in Hydroxyapatite structure by varied cations as Na, Mg, Sr and Mn, which result in changes in various structural pro perties as crystallinity and morphology. Pure calcium hydroxyapatite (S1) and Cr loaded hydroxyl apatite (S2, S3, S4 and S5) of different chromium concentrations have been prepared by wet precipitated method. An in-vitro examination is essential to investigate the mechanism of the deficient HA and tissue interface reaction by preparing SBF (Simulated Body Fluid) through the elemental and chemical analysis of Ca, P and Cr. FTIR used to analyze the samples after incubation in SBF for 24 day. PH of the samples also was measured at the first period of immersion time. At high loading of chromium ions, the formation of carbonate apatite decrease. The concentrations of the chromium in the Cr_HA crystal during the soaking in SBF are very safe dose for human.

Share and Cite:

M. Sallam, S. , M. Tohami, K. , M. Sallam, A. , I. Abo Salem, L. and Adel Mohamed, F. (2012) The influence of chromium ions on the growth of the calcium hydroxyapatite crystal. Journal of Biophysical Chemistry, 3, 283-286. doi: 10.4236/jbpc.2012.34034.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Zapanta LeGeros, R. (1991) Calcium phosphates in oral biology and medicine. Karger, New York.
[2] Pang, Y.X. and Bao, X. (2003) Influence of temperature, ripening time and calcination on the morphology and crystallinity of hydroxyapatite nanoparticles. Journal of the European Ceramic Society, 23, 1697-1704. doi:10.1016/S0955-2219(02)00413-2
[3] Wakamura, M., Kandori, K. and Ishikawa, T. (1997) Influence of chromium (III) on the formation of calcium hydroxyapatite. Polyhedron, 16, 2047-2053. doi:10.1016/S0277-5387(96)00513-X
[4] Jeejebhoy, K.N., Chu, R.C., Marliss, E.B., Greenberg, G.R. and Bruce-Robertson, A. (1977) Chromium deficiency, glucose intolerance and neuropathy reversed by chromium supplementation in a patient receiving long-term total parenteral nutrition. American Journal of Clinical Nutrition, 30, 531-538.
[5] Anderson, R.A. (1998) Chromium, glucose intolerance and diabetes. Journal of the American College of Nutrition, 17, 548-555.
[6] Anderson, R.A. (2000) Chromium in the prevention and control of diabetes. Diabetes and Metabolism, 26, 22-27.
[7] Chang, X., Jorgensen, A.M., Bardrum, P., Led, J.J. (1997) Solution structures of the R6 human insulin hexamer. Biochemistry, 36, 9409-9422.
[8] Benedict, C., Hallschmid, M., Hatke, A., Schultes, B., Fehm, H.L., Born, J. and Kern, W. (2004) Intranasal insulin improves memory in humans. Psychoneuroendocrinology, 29, 1326-1334. doi:10.1016/j.psyneuen.2004.04.003
[9] Kokubo, T. and Takadama, H. (2006) How useful is SBF in predicting in vivo bone bioactivity? Biomaterials, 27, 2907-2915. doi:10.1016/j.biomaterials.2006.01.017
[10] Boucetta, C., Kacimi, M., Ensuque, A., et al. (2004) Oxidative dehydrogenation of propane over chromium-loaded calcium-hydroxyapatite. Applied Catalysis A: General, 356, 201-210. doi:10.1016/j.apcata.2009.01.005
[11] Rey, C., Renugo Palakrishnan, V., Collins, B. and Glimcher, M.J. (1991) Fourier transform infrared spectroscopy study of the carbonate ions in bone mineral during aging. Calcified Tissue International, 49, 251-258. doi:10.1007/BF02556214

Copyright © 2023 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.