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has been cited by the following article:

• TITLE: Synthesis and Anti-Cancer Activities of Resveratrol Derivatives

  AUTHORS: Xing Zheng, Liuying Yu, Xu Yao, Bo Lv, Zehua Yang, Qutong Zheng, Haiying Duan, Chen Song, Hailong Xie

  KEYWORDS: Resveratrol Derivatives, Wittig-Horner Reaction, MTT Method, Breast Carcinoma, Gastric Carcinoma

  JOURNAL NAME: Open Journal of Medicinal Chemistry, Vol.6 No.3, September 30, 2016

  ABSTRACT: A novel series of resveratrol derivatives were synthesized according to Wittig-Horner reaction with 3,5-dihydroxybenzyl alcohol or 3,5-dimethoxybenzyl alcohol or 4-hydroxybenzyl alcohol as raw material and the inhibitory activities on breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) in vitro were evaluated by the standard methyl thiazole tetrazolium (MTT) method. The result of biological test shows that some of resveratrol derivatives possess stronger anti-cancer activities than 5-FU. Compound 5c shows the strongest activity against breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) with IC50 value of 50.19 ± 1.02 μM, 122.68.27 ± 2.04 μM, compared to that IC50 value of 5-FU is 98.59±3.61 μM,156.74±6.16 μM, respectively.