TITLE:
Peripheral Analgesic and Anti-Inflammatory Effects of Smilax canariensis in an Animal Model
AUTHORS:
Sandra Dévora, Susana Abdala, Domingo Martín-Herrera
KEYWORDS:
Smilax canariensis, Smilacaceae, Medicinal Plant, Folk Medicine, Analgesic Activity, Anti-Inflammatory Activity
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.6 No.8,
August
24,
2015
ABSTRACT: Smilax canariensis Brouss. ex Willd. is an endemic plant of the Canary Islands. Its rhizomes, leaves and stems have been traditionally used in Canary folk medicine to treat a wide variety of conditions including pain. Our objective is to investigate the analgesic and anti-inflammatory activities of different extracts of S. canariensis in Swiss mice, using established biological models for pain and inflammation, such as phenylquinone writhing test, formalin test, tail-flick test and mouse paw edema induced by carrageenan. Oral administration of S. canariensis extracts significantly reduce writhing episodes evoked by phenylquinone injection in a dose-dependent manner; and higher doses result in a reduction of pain similar to or higher than that of the reference drug piroxicam (59.56%; p