TITLE:
Does an “Overactive to Underactive Bladder Transition” Phenomenon Exist in a Rat Lumbar Spinal Canal Stenosis Model?
AUTHORS:
Noritoshi Sekido, Jun Kida, Daisuke Wakamatsu, Hiroki Okada, Hidekazu Matsuya
KEYWORDS:
Underactive Bladder, Detrusor Underactivity, Lumbar Canal Stenosis, Animal Model, Overactive Bladder
JOURNAL NAME:
Open Journal of Urology,
Vol.5 No.5,
May
8,
2015
ABSTRACT: Purpose: To investigate the association
between the maximum cystometric capacity (MCC) and other cystometric parameters
in lumbar canal stenosis (LCS) rats. Material and Methods: One small hole was
drilled at the fifth lumbar vertebral arch (Sham), and a rectangular piece of
silicone rubber was then placed in the epidural space (LCS) of Wister rats. Two
weeks after surgery, awake cystometry was performed. LCS rats were divided into
three groups: Group A (n = 5, MCC 1.81 mL). Cystometric parameters were
investigated in sham and LCS groups. Results: MCC did not significantly
correlate to the frequency of non-voiding contractions (NVCs), voided volume
(VV), or maximum intravesical pressure during voiding (Pmax), but significantly
positively correlated to postvoid residual urine volume (PVR) and residual
urine rate (RUR) (Spearman’s correlation coefficients (ρ) = 0.8973 (p