TITLE:
Kinetics of Serum and Local Leukotriene B4 Response in Experimental Intravaginal Trichomoniasis by T. vaginalis Isolates from Symptomatic and Asymptomatic Women
AUTHORS:
Amany M. Eida, Omima M. Eida, Ahmed Saied Salem
KEYWORDS:
Trichomoniasis, Clinical Isolates, Experimental Study, Pathogenesis, Immune Response, Leukotriene B4
JOURNAL NAME:
Advances in Infectious Diseases,
Vol.5 No.1,
February
28,
2015
ABSTRACT: Trichomoniasis is most
common sexually transmitted disease caused by T. vaginalis. The clinical
manifestation varies from severe manifestation to asymptomatic condition.
However, the exact virulence markers led to varied symptomatology was not well
clarified. The role of leukotriene B4 (LTB4) in the
pathogenesis of many parasitic diseases has been reported. The present study reports
the leukotriene B4 levels on different days post infection (3rd,
7th, 14th, 21st and 28th d.p.i.) in serum and vaginal washes (VWs) and vaginal
tissues of mice infected intravaginally with T. vaginalis isolates from
10 symptomatic and 10 asymptomatic women. A significant increase in LTB4 was observed on the 3rd to 28th d.p.i. in serum and VWs of mice infected with T.
vaginalis isolates from asymptomatic as compared to symptomatic women. The
present study also reports the histopathological changes of the posterior
vaginal fornix’s and upper portion of the vagina of mice infected intravaginally with T. vaginalis isolates from 10 symptomatic and 10 asymptomatic women. The results show
that there are no significant differences between symptomatic and asymptomatic
isolates regarding histopathological changes.