Ohe, Y., Ichinose, Y., Nakagawa, K., Tamura, T., Kubota, K., Yamamoto, N., Adachi, S., Nambu, Y., Fujimoto, T., Nishiwaki, Y., Saijo, N. and Fukuoka, M. (2008) Efficacy and Safety of Two Doses of Pemetrexed Supplemented with Folic Acid and Vitamin B12 in Previously Treated Patients with Non-Small Cell Lung Cancer. Clinical Cancer Re- search, 14, 4206-4212. http://dx.doi.org/10.1158/1078-0432.CCR-07-5143

has been cited by the following article:

• TITLE: Good Response to Pemetrexed after Treatment Failure with Another Thymidylate Synthase Inhibitor in Lung Adenocarcinoma: A Case Report

  AUTHORS: Fumihiko Hirai, Eiko Inamasu, Gouji Toyokawa, Tsukihisa Yoshida, Kaname Nosaki, Tomoyoshi Takenaka, Masafumi Yamaguchi, Mitsuhiro Takenoyama, Takashi Seto, Yukito Ichinose

  KEYWORDS: Pemetrexed, S-1, Thymidylate Synthase

  JOURNAL NAME: Journal of Cancer Therapy, Vol.5 No.8, July 10, 2014

  ABSTRACT: Pemetrexed is an antimetabolic agent and is well-known as a potent inhibitor of thymidylate synthase (TS). It also inhibits dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyl transferase (GARFT). We reported an intriguing case in which a non-small cell lung cancer patient who was refractory to pretreatment with S-1, a strong TS inhibitor, showed good response to pemetrexed treatment.