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Good Response to Pemetrexed after Treatment Failure with Another Thymidylate Synthase Inhibitor in Lung Adenocarcinoma: A Case Report

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DOI: 10.4236/jct.2014.58085    1,995 Downloads   2,731 Views  


Pemetrexed is an antimetabolic agent and is well-known as a potent inhibitor of thymidylate synthase (TS). It also inhibits dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyl transferase (GARFT). We reported an intriguing case in which a non-small cell lung cancer patient who was refractory to pretreatment with S-1, a strong TS inhibitor, showed good response to pemetrexed treatment.

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The authors declare no conflicts of interest.

Cite this paper

Hirai, F. , Inamasu, E. , Toyokawa, G. , Yoshida, T. , Nosaki, K. , Takenaka, T. , Yamaguchi, M. , Takenoyama, M. , Seto, T. and Ichinose, Y. (2014) Good Response to Pemetrexed after Treatment Failure with Another Thymidylate Synthase Inhibitor in Lung Adenocarcinoma: A Case Report. Journal of Cancer Therapy, 5, 766-768. doi: 10.4236/jct.2014.58085.


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