TITLE:
Good Response to Pemetrexed after Treatment Failure with Another Thymidylate Synthase Inhibitor in Lung Adenocarcinoma: A Case Report
AUTHORS:
Fumihiko Hirai, Eiko Inamasu, Gouji Toyokawa, Tsukihisa Yoshida, Kaname Nosaki, Tomoyoshi Takenaka, Masafumi Yamaguchi, Mitsuhiro Takenoyama, Takashi Seto, Yukito Ichinose
KEYWORDS:
Pemetrexed, S-1, Thymidylate Synthase
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.5 No.8,
July
10,
2014
ABSTRACT:
Pemetrexed is an
antimetabolic agent and is well-known as a potent inhibitor of thymidylate
synthase (TS). It also inhibits dihydrofolate reductase (DHFR) and glycinamide
ribonucleotide formyl transferase (GARFT). We reported an intriguing case in
which a non-small cell lung cancer patient who was refractory to pretreatment
with S-1, a strong TS inhibitor, showed good response to pemetrexed treatment.