Aihara, Y., Yoshiji, H., Noguchi, R., Kaji, K., Namisaki, T., Shirai, Y., Douhara, A., Moriya, K., Kawaratani, H. and Fukui, H. (2013) Direct Renin Inhibitor, Aliskiren, Attenuates the Progression of Non-Alcoholic Steatohepatitis in the Rat Model. Hepatology Research, 43, 1241-1250.
http://dx.doi.org/10.1111/hepr.12081

has been cited by the following article:

• TITLE: Aliskiren Augments the Activities of Anti-Oxidant Enzymes in Liver Homogenates of DOCA Salt-Induced Hypertensive Rats

  AUTHORS: Sahar Kamal

  KEYWORDS: Aliskiren, DOCA Hypertensive Rats, Anti-Oxidant Enzymes, TBARS, Liver

  JOURNAL NAME: Advances in Enzyme Research, Vol.2 No.2, June 10, 2014

  ABSTRACT: Hypertension is a serious problem that is recently thought to be associated with damaging effects on target organs partially via oxidative stress. On the other hand, there is accumulating literature describing some sort of therapeutic interaction between antioxidant enzymes in vital organs and hypertension. Therefore, the aim of this study is to investigate the possible effect of a direct renin inhibitor, aliskiren, used in treatment of hypertension via renin-angiotensin-aldosterone system (RAAS), on selected anti-oxidant enzymes in hepatic homogenates in DOCA salt-induced hypertesnive albino rats. Thirty male wister albino rats were assigned randomly into 3 groups (n = 10/ group). Group 1 received no treatement and serves as control. Group 2 received 0.5% carboxymethylcellulose sodium ip as a solvent of aliskiren, as a direct renin inhibitor (DRI). Group 3 received aliskiren 100 mg/kg/day ip for 4 weeks through gastric tube. Systolic blood pressure (SBP) was measured every week and its mean was recorded at the end of the study. Superoxide dismutase (SOD) enzyme in RBCs lysates, activities of catalase (CAT) and glutathione peroxidase enzymes and thiobarbituric acid reactive substance (TBARS), as a marker of lipid peroxidation, in hepatic homogenates were measured at the end of the study. DRI produced a marked reduction in mean SBP of hypertensive rats. It also significantly (p