TITLE:
Use of a naturally occurring codon bias for identifying topoisomerase mutations in ciprofloxacin resistant Escherichia coli using PCR and future prospects with other bacterial genera: A pilot study
AUTHORS:
Subramanian Krishnan, Dheepikaa Balasubramanian, B. Appala Raju, Baddireddi Subadhra Lakshmi
KEYWORDS:
Escherichia coli Gyrase A; Codon Bias; Mutation; Ciprofloxacin Resistance; PCR
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.2 No.4,
November
23,
2012
ABSTRACT: We developed a novel PCR method aimed at identi- fying and amplifying native codon sequences of muta- tion-prone amino acids in DNA gyrase implicated in quinolone resistance using a naturally occurring co- don bias in E. coli DNA gyrase A.