TITLE:
Oocyte Cryopreservation before Tumorectomy in Gorlin-Goltz Syndrome with Recurrent Ovarian Fibroma: A Case Report
AUTHORS:
Makoto Chihara, Atsushi Fujimoto, Kanna Ogi, Tatsuya Ishiguro, Kunihiko Yoshida, Masayuki Sekine, Koich Takakuwa, Hiroki Fujikawa, Yutaka Shimomura, Takayuki Enomoto
KEYWORDS:
Case Reports, Cryopreservation, Fibroma, Gorlin-Goltz Syndrome, Recurrence
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.8 No.10,
August
23,
2018
ABSTRACT: Background: Gorlin-Goltz syndrome is a very rare syndrome that
reportedly occurs in 1 of 235,800 people in Japan. The proportion of women with Gorlin-Goltz syndrome
complicated with an ovarian fibroma ranges from 12.5% to 17.0%. Some surgical
cases of Gorlin-Goltz syndrome with an ovarian tumor have been reported.
However, no studies have mentioned subsequent fertility preservation by using
oocyte cryopreservation process. Case: In this case report, the patient
with Gorlin-Goltz syndrome underwent laparotomy for bilateral ovarian
fibrothecoma at 15 years of age. At 20 years of age, a recurrent ovarian tumor
was detected in the remaining ovary. During the follow-up, we detected an
increase in its size. As tumor torsion requiring left salpingo-oophorectomy was
possible, tumorectomy was considered. However, her
anti-Müllerian hormone level was low. As she was at risk for premature ovarian
failure after tumorectomy, we planned to cryopreserve her oocytes to preserve
her fertility before tumorectomy. Outcome: When
the patient underwent surgery, the diameter of her left ovarian tumor was found
to have increased to 56 mm. Egg collection was performed twice, and two
oocytes were cryopreserved. Subsequently, she underwent tumorectomy of the left
ovarian tumor. No recurrence has been observed. Conclusion: If a recurrent ovarian tumor is detected in patients with
Gorlin-Goltz syndrome and a low anti-Müllerian hormone level, cryopreservation
of oocytes before tumorectomy may be effective for preserving their fertility.