Cheng, A.L., Hsu, C.H., Lin, J.K., Hsu, M.M., Ho, Y.F., Shen, T.S., Ko, J.Y., Lin, J.T., Lin, B.R., Ming-Shiang, W., Yu, H.S., Jee, S.H., Chen, G.S., Chen, T.M., Chen, C.A., Lai, M.K., Pu, Y.S., Pan, M.H., Wang, Y.J., Tsai, C.C. and Hsieh, C.Y. (2001) Phase 1 Clinical Trial of Curcumin, a Chemopreventive Agent, in Patients with High-Risk or Pre-Malignant Lessons. Anticancer Research, 21, 2895-2900.

has been cited by the following article:

• TITLE: Curcumin Inhibits Adipogenesis Elicited by Clozapine in 3T3-L1 Cells

  AUTHORS: Satoru Sakuma, Maki Sumida, Asami Sakabe, Ayaka Nakamura, Chisato Noda, Kaho Tsujimoto, Maimi Kobayashi, Tomohiko Sano, Yohko Fujimoto, Tetsuya Kohda

  KEYWORDS: Clozapine, Curcumin, Adipocyte Differentiation, 3T3-L1 Cell, Atypical Antipsychotic Drug

  JOURNAL NAME: Food and Nutrition Sciences, Vol.9 No.5, May 24, 2018

  ABSTRACT: Although clozapine (CZP), which is used for schizophrenia treatment, causes weight gain, the mechanism remains unclear. We recently reported that the naturally occurring compound curcumin (CUR) suppresses adipogenesis in 3T3-L1 cells. The aims of the present study were to determine the mechanism by which CZP induces adipocyte differentiation of 3T3-L1 cells, and whether CUR reduces CZP-induced adipogenesis. We found that cells grown in the presence of CZP had significantly higher triacylglycerol levels, numbers of lipid-filled adipocytes, and mRNA expression levels of CCAAT-enhancer binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ) than those grown without CZP. Treatment with CZP plus CUR resulted in major reductions in these four parameters. These results suggest that CZP enhances adipogenesis in 3T3-L1 cells via the C/EBPα-PPARγ pathway and that by interrupting CZP’s effects, CUR might be a potent agent for preventing CZP-induced weight gain.