TITLE:
Recurrent Transient Osteoporosis during Pregnancy and Treatment with Oral Bisphosphonates: A Case Report
AUTHORS:
Pavlos Sachsanidis, Mario Valerio Tartagni, Urs Graf
KEYWORDS:
Transient Osteoporosis, Pregnancy, Oral Treatment, Bisphosphonates
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.7 No.10,
October
11,
2017
ABSTRACT: Transient osteoporosis of the hip (TOH), also known
as “Bone marrow edema Syndrome”, is a rare disorder mainly affecting pregnant
women in their third trimester, as well as middle-aged, overweight men. A
30-year-old Caucasian female G2P2, with history of transient osteoporosis of
both ankles and C-Section during the last pregnancy in 2011, presented
progressively severe bilateral hip pain with onset already in the 12th gestational week. Imaging of the pelvis and bilateral hips with MRI obtained 6
days after the C-Section demonstrated bilateral bone-marrow edema of the hips.
The patient was treated with a monthly single dose of 150 mg ibandronate acid
per os, for 3 months and physiotherapy. Repeated MRI performed 5 months
postpartum revealed a complete remission of the disease. In contrast to the
first onset of transient osteoporosis during the first pregnancy, which was
only treated conservatively without bisphosphonates, the remission of the
disease and patient’s recovery with oral ibandronate therapy showed to be 4
months shorter. This case is unique in literature for both describing the onset
of this rare disease twice in the same patient as well as its oral therapeutic
approach.