TITLE:
Risk Factors Associated with In-Hospital Post-Chemotherapy Mortality in Patients with Malignant Musculoskeletal Tumors
AUTHORS:
Toru Akiyama, Kazuo Saita, Hirotaka Chikuda, Hiromasa Horiguchi, Kiyohide Fushimi, Hideo Yasunaga
KEYWORDS:
Chemotherapy, Sarcoma, In-Hospital Mortality, Chemotherapy-Related Death, Japanese Diagnosis Procedure Combination Database
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.7 No.6,
June
1,
2016
ABSTRACT: Introduction: Reducing the in-hospital post-chemotherapy mortality rate
in patients with malignant musculoskeletal tumors is important for improving
treatment outcome. This study aimed to investigate the risk factors associated
with in-hospital post-chemotherapy mortality in patients with primary malignant
musculoskeletal tumors. Methods: Using a Japanese national inpatient database, we
retrospectively identified 5039 patients (2920 men and 2131 women; mean age, 39
years) who underwent curative chemotherapy for malignant musculoskeletal tumors
between 2007 and 2010. We extracted data on the patients’ characteristics,
complications, chemotherapeutic agent use, comorbidities, and in-hospital death.
Logistic regression analyses were performed to analyze factors affecting
in-hospital post-chemotherapy death in these patients. Results: The overall
in-hospital mortality rate was 1.1%. Higher in-hospital mortality rates were
significantly associated with a greater volume of blood transfusion (>2500
mL) (odds ratio [OR], 49.71; 95% confidence interval [CI], 22.24 - 111.12; p