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http://dx.doi.org/10.1016/S0190-9622(99)70442-1

has been cited by the following article:

• TITLE: Evaluation of Antioxidant and Anti-Inflammatory Effect of Rhododendron brachycarpum Extract Used in Skin Care Product by in Vitro and in Vivo Test

  AUTHORS: Amal Kumar Ghimeray, Ha Youn Lee, Young Hoon Kim, Eun Kyung Ryu, Moon Sik Chang

  KEYWORDS: Antioxidant, Anti-Inflammatory, Cytotoxic, Rhododendron brachycarpum, Cosmetics

  JOURNAL NAME: Technology and Investment, Vol.6 No.2, April 29, 2015

  ABSTRACT: In this study, we aimed to observe the cytotoxicity, antioxidant and anti-inflammatory activity of Rhododendron brachycarpum extract (RbE) in RAW 264.7 macrophage cell in vitro and the anti-inflammatory or soothing effect of RbE formulated cream (Multicalm-RHTM) on experimentally induced acute irritated skin in healthy subjects in vivo. In vitro study revealed that RbE significantly inhibited NO and ROS generation in a dose dependent manner without cytotoxicity. In clinical test, Multicalm-RHTM cream siginificantly reduced the SLS-enduced erythema after D5 compared to that of placebo. Overall, it can be concluded that the RbE is a non-cytotoxic, antioxidant and anti-irritant agent which can be used as a potent functional ingredient in cosmetics. Likewise, the in vivo clinical study shows that Multicalm-RHTM cream which contains 3% RbE can be used as an effective skin soothing agent.