Evaluation of Antioxidant and Anti-Inflammatory Effect of Rhododendron brachycarpum Extract Used in Skin Care Product by in Vitro and in Vivo Test


In this study, we aimed to observe the cytotoxicity, antioxidant and anti-inflammatory activity of Rhododendron brachycarpum extract (RbE) in RAW 264.7 macrophage cell in vitro and the anti-inflammatory or soothing effect of RbE formulated cream (Multicalm-RHTM) on experimentally induced acute irritated skin in healthy subjects in vivo. In vitro study revealed that RbE significantly inhibited NO and ROS generation in a dose dependent manner without cytotoxicity. In clinical test, Multicalm-RHTM cream siginificantly reduced the SLS-enduced erythema after D5 compared to that of placebo. Overall, it can be concluded that the RbE is a non-cytotoxic, antioxidant and anti-irritant agent which can be used as a potent functional ingredient in cosmetics. Likewise, the in vivo clinical study shows that Multicalm-RHTM cream which contains 3% RbE can be used as an effective skin soothing agent.

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Ghimeray, A. , Lee, H. , Kim, Y. , Ryu, E. and Chang, M. (2015) Evaluation of Antioxidant and Anti-Inflammatory Effect of Rhododendron brachycarpum Extract Used in Skin Care Product by in Vitro and in Vivo Test. Technology and Investment, 6, 105-111. doi: 10.4236/ti.2015.62011.

Conflicts of Interest

The authors declare no conflicts of interest.


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