Article citationsMore>>
Deuschl, G., Schade-Brittinger, C., Krack, P., Volkmann, J., Schäfer, H., Bötzel, K., Daniels, C., Deutschländer, A., Dillmann, U., Eisner, W., Gruber, D., Hamel, W., Herzog, J., Hilker, R., Klebe, S., Kloss, M., Koy, J., Krause, M., Kupsch, A., Lorenz, D., Lorenzl, S., Mehdorn, H.M., Moringlane, J.R., Oertel, W., Pinsker, M.O., Reichmann, H., Reuss, A., Schneider, G.H., Schnitzler, A., Steude, U., Sturm, V., Timmermann, L., Tronnier, V., Trottenberg, T., Wojtecki, L., Wolf, E., Poewe, W. and Voges, J., German Parkinson Study Group, Neurostimulation Section (2006) A Randomized Trial of Deep-Brain Stimulation for Parkinson’s Disease. The New England Journal of Medicine, 355, 896-908.
http://dx.doi.org/10.1056/NEJMoa060281
has been cited by the following article:
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TITLE:
Five-Year Outcomes of Bilateral Subthalamic Nucleus Stimulation in Japanese Patients with Parkinson’s Disease
AUTHORS:
Atsushi Umemura, Miwako Miyata, Yuichi Oka, Kenji Okita, Genko Oyama, Yasushi Shimo, Nobutaka Hattori
KEYWORDS:
Deep Brain Stimulation, Subthalamic Nucleus, Parkinson’s Disease, Long-Term Outcome, Adverse Effect
JOURNAL NAME:
Advances in Parkinson's Disease,
Vol.4 No.2,
April
10,
2015
ABSTRACT: Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is widely performed for medically refractory Parkinson’s disease (PD). Several western studies have examined the long-term outcomes of STN DBS. However, the long-term outcomes in Japanese patients have not been reported. Methods: We studied the long-term outcomes of STN DBS in Japanese patients with PD. Fifty-five consecutive patients treated with bilateral STN DBS were followed for 5 years after surgery. Each patient underwent Unified Parkinson’s Disease Rating Scale assessments preoperatively and 1 and 5 years after surgery. Results: Twelve patients (22%) were lost to follow up within 5 years. Among them, 7 died and 5 became bed ridden because of PD deterioration. In the 43 patients followed for 5 years, STN DBS significantly improved motor function. The cardinal motor symptoms of tremor, rigidity, and bradykinesia in medication-on periods were significantly better than baseline 5 years after DBS. However, axial motor symptoms of speech, gait and postural stability gradually deteriorated and significantly worsened 5 years after DBS. Motor complications, including dyskinesia and motor fluctuations, significantly improved after DBS with a marked reduction in dopaminergic medication. These effects were maintained 5 years after DBS. Frequently, persisting adverse effects included apraxia of eyelid opening and dysarthria. Conclusions: STN DBS significantly improved motor symptoms in patients with advanced PD. These effects were maintained over 5 years in most patients. However, some showed rapid PD progression even after STN DBS. Other treatments for the axial symptoms and disease progression are needed in long-term PD treatment.
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