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has been cited by the following article:

• TITLE: Influence of Genetic Polymorphism of Styrene-Metablizing Enzymes on Occupational Exposure Monitoring to Styrene

  AUTHORS: Wei Qu, Fang Zhang

  KEYWORDS: Styrene, Mandelic Acid (MA), Phenylglyoxylic Acid (PGA), Phenyl Hydroxyethyl Mercapturic Acids (PHEMA), Biological Monitoring, Genetic Polymorphisms

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.3 No.3, March 18, 2015

  ABSTRACT: In this study, we selected 58 styrene-exposed workers, measured personal styrene exposure, evaluated genotypes relevant drug-metabolizing enzymes (CYP2E1, EPHX1, GSTM1 and GSTT1) which may explain the variability in the urinary metabolite excretion. The results showed that, in different levels of styrene exposure groups, there is a significant association between urinary metabolites and some genotypes of styrene-metabolizing enzymes, including CYP2E1 (5-flanking region, RsaI/PstI), GSTM1(gene deletions) and EPHX1(predicted activity).