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Influence of Genetic Polymorphism of Styrene-Metablizing Enzymes on Occupational Exposure Monitoring to Styrene

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DOI: 10.4236/jbm.2015.33005    3,096 Downloads   3,376 Views  
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ABSTRACT

In this study, we selected 58 styrene-exposed workers, measured personal styrene exposure, evaluated genotypes relevant drug-metabolizing enzymes (CYP2E1, EPHX1, GSTM1 and GSTT1) which may explain the variability in the urinary metabolite excretion. The results showed that, in different levels of styrene exposure groups, there is a significant association between urinary metabolites and some genotypes of styrene-metabolizing enzymes, including CYP2E1 (5-flanking region, RsaI/PstI), GSTM1(gene deletions) and EPHX1(predicted activity).

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Qu, W. and Zhang, F. (2015) Influence of Genetic Polymorphism of Styrene-Metablizing Enzymes on Occupational Exposure Monitoring to Styrene. Journal of Biosciences and Medicines, 3, 35-38. doi: 10.4236/jbm.2015.33005.

References

[1] Sarmaovvá, J., Tynková, L., Süsová, S., Cut, I. and Soucek, P. (2000) Genetic Polymorphisms of Biotransformation Enzymes: Allele Frequencies in the Population of Czech Republic. Pharmacogenetics, 10, 781-788. http://dx.doi.org/10.1097/00008571-200012000-00003
[2] VeMina, A, Galati, R., Falasca, G., et al. (2001) Metabolic Polymorphisms and Urinary Biomarkers in Subjects with Low Benzene Exposure. Journal of Toxicology and Environmental Health, 64, 607-618. http://dx.doi.org/10.1080/152873901753246214
[3] Kim, H., Wang, R.S., Elovaara, E., et al. (1997) Cytochrome P450 Isoenzymes Responsible for the Metabolism of Toluene and Styrene in Human Liver Microsomes. Xenobiotica, 27, 657-665. http://dx.doi.org/10.1080/004982597240253

  
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