Influence of Genetic Polymorphism of Styrene-Metablizing Enzymes on Occupational Exposure Monitoring to Styrene

Wei Qu, Fang Zhang^*

Shandong Academy of Occupational Heath and Occupational medicine, Jinan, China.

DOI: 10.4236/jbm.2015.33005                

Abstract

In this study, we selected 58 styrene-exposed workers, measured personal styrene exposure, evaluated genotypes relevant drug-metabolizing enzymes (CYP2E1, EPHX1, GSTM1 and GSTT1) which may explain the variability in the urinary metabolite excretion. The results showed that, in different levels of styrene exposure groups, there is a significant association between urinary metabolites and some genotypes of styrene-metabolizing enzymes, including CYP2E1 (5-flanking region, RsaI/PstI), GSTM1(gene deletions) and EPHX1(predicted activity).

Keywords

Styrene, Mandelic Acid (MA), Phenylglyoxylic Acid (PGA), Phenyl Hydroxyethyl Mercapturic Acids (PHEMA), Biological Monitoring, Genetic Polymorphisms

Conflicts of Interest

The authors declare no conflicts of interest.

References

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